International Journal of Advanced Biological and Biomedical Research

Emerging Antibiotic Resistance in Gram-Positive Bacteria, with Focus on Staphylococcus Aureus, Enterococcus Spp., and Streptococcus Pneumoniae

Olumakinde Charles Omiyale; Favour Onaskohare Okunbi; Confidence Damian Oparah; Victor Nduka Eluwa; Rosemary Modupeoluwa Awolade; Precious Ifechukwuni Ikuni; Muhammad Bello Demola; Christianah Oluwatosin Agboola; Temitope Oluwapelumi Babalola; Abdul-Hanan Saani Inusah; Abigail Daniel Agbo; Onyekachi Uchenna Uchejuru; Minasu Benjamin Oke; Auguatine Stanley Ugbobuaku

Volume 12, Issue 3 , July 2024, , Pages 218-236

https://doi.org/10.48309/ijabbr.2024.2017880.1476

Abstract

Antibiotic resistance is becoming more prevalent, which presents as an urgent risk to world-wide well-being, necessitating an urgent exploration of its mechanisms, implications, and ... Read More

Water Extraction of Plant (Momordica Charantia) Reduced Oxidative and Colonic Mucosal Inflammation in Colotic Male Balb/c Mice

Olumakinde Charles Omiyale; Edu Zainab; Ngozi Maryann Nebolisa; Ayomide Balikis Asebebe; Daniel Ebubechi Obasi; Adeleye Adegboyega Edema; Sulaimon Olajuwon Abdul; Uchechukwu Divine Donatus; Obinna Kenneth Didigwu; Derrick Tochukwu Menankiti; Faith Philip Edem; Blessing Oluwatobi Ojo

Volume 12, Issue 3 , July 2024, , Pages 300-318

https://doi.org/10.48309/ijabbr.2024.2020784.1483

Abstract

Medicinal plants are the most easily accessible health resource for the community and frequently the people’s preferred option. Momordica charantia (bitter gourd) is a member ... Read More Medicinal plants are the most easily accessible health resource for the community and frequently the people’s preferred option. Momordica charantia (bitter gourd) is a member of the Cucurbitaceous plant used as a vegetable and in traditional medicine. This study aimed to evaluate the effect of water extract of Momordica charantia leaves on male Balb/c mice with acute ulcerative colitis. 28 male mice were acclimatized and equally divided into four groups. The control group was given normal saline; the dextran sulphate sodium group (DSS) received 3% Dextran sulfate sodium in drinking water for seven days; the water extract of Momordica charantia + dextran sulphate sodium group (WEMC+DSS) received water extract of Momordica Charantia for seven days before dextran sulphate sodium (DSS) was administered; the water extract of Momordica charantia group (WEMC) received water extract of Momordica charantia (150mg/kg b.wt.) for 14 days. The mice were daily weighed and sacrificed on the 15th day of the experiment. Their colon and brain were collected for evaluation of disease activity indices (DAI) of colitis, and oxidative and inflammatory damage via biochemical and histological assessments. Results obtained showed no significant difference at (p<0.05) in DAI among the groups. The WEMC+DSS when compared with the DSS group had significantly higher catalase (272.9±54.8, 175.1+12.5, and 200.2±29.7), superoxide dismutase–SOD (347.7±37.5, 223.9±13.1, and 254.9±38.8), and glutathione peroxidase–GPx (28.6±2.20, 27.3±1.24, and 27.8±1.57) activities, and SOD/ (catalase+GPX) ratio (0.01±0.00, 0.003±0.00, and 0.01±0.002) and reduced hydrogen peroxide concentration (7.63±0.54, 4.33±1.28, and 5.71±0.75) in both colon and brain cytosolic fractions, respectively. Histological examination showed transmural inflammation in the DSS group as against mild mucosal inflammation in WEMC+DSS. This result shows that water extract of Momordica charantia has the potential to reduce colitis-induced oxidative damage and inflammation. Based on the results of this study, it can be concluded that the water extract of Momordica charantia leaves has the potential to mitigate oxidative damage and inflammation induced by ulcerative colitis in male Balb/c mice. Although there was no significant difference in disease activity indices among the groups, the group treated with the water extract of Momordica charantia before DSS administration showed significantly higher levels of antioxidant enzyme activities and lower levels of hydrogen peroxide concentration in both colon and brain cytosolic fractions compared to the DSS group.

Effects of Jicama- (Pachyehizus erous) Based Oral Rehydration Solution on Intestinal Alkaline Phosphatase in Diarrheagenic Rats

Olumakinde Charles Omiyale; Mubaraq Damilare Yussuf; Esther Omolabake Kehinde; Oluwatoyin Olabimpe Olofin

Volume 12, Issue 2 , April 2024, , Pages 130-140

https://doi.org/10.48309/ijabbr.2024.2017216.1472

Abstract

Diarrhea results in the disruption of intestinal architecture and marked decrease in the activity of intestinal brush border enzymes, including Alkaline phosphatase (ALP). This study ... Read More

Hypoglycemic and Antioxidants Activities of Carica Papaya Leaves

Olumakinde Charles Omiyale; Blessing Ifeoluwa Ogunniran; Mercy Ogochukwu Ezeh; Mubaraq Damilare Yussuf; Confidence Damian Oparah; Fawaz Isshak

Volume 12, Issue 2 , April 2024, , Pages 141-154

https://doi.org/10.48309/ijabbr.2024.2017219.1473

Abstract

The objective of the current study was to assess the ethanolic and methanolic extracts of Carica papaya's hypoglycemic effects. Yeast glucose uptake, muscle glucose uptake, and glucose ... Read More

Phytochemical Profile and Antioxidant Properties of Extracts from Sargassum flutans

Omiyale Olumakinde Charles; Yussuf Mubaraq Damilare; Oparah Confidence Damian; Jokoh Peterkings Eriuroro; Ikuni Precious Ifechukwukuni; Okpara Chidiebere Cyril; Olofin Oluwatoyin Olabimpe; Ishiaq Abdulwasiu Dolapo; Ogunleye Felix Iyanu; Adeleye Hannah Oreoluwa

Volume 11, Issue 4 , October 2023, , Pages 261-276

https://doi.org/10.48309/ijabbr.2023.2010788.1460

Abstract

Many seaweeds, most notably brown algae, are suitable for human consumption. These plants have various possible biological actions and significant phytochemical components. The ethylacetate ... Read More

International Journal of Advanced Biological and Biomedical Research

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Author = Charles, Omiyale Olumakinde

Emerging Antibiotic Resistance in Gram-Positive Bacteria, with Focus on Staphylococcus Aureus, Enterococcus Spp., and Streptococcus Pneumoniae

Abstract

Water Extraction of Plant (Momordica Charantia) Reduced Oxidative and Colonic Mucosal Inflammation in Colotic Male Balb/c Mice

Abstract

Effects of Jicama- (Pachyehizus erous) Based Oral Rehydration Solution on Intestinal Alkaline Phosphatase in Diarrheagenic Rats

Abstract

Hypoglycemic and Antioxidants Activities of Carica Papaya Leaves

Abstract

Phytochemical Profile and Antioxidant Properties of Extracts from Sargassum flutans

Abstract